At the center of those murders was Emma Duval (played by Willa Fitzgerald), a teenage girl who is somehow tied to the town's dark past. The first two seasons were situated in the fictional town of Lakewood, where a string of murders took place.

Blotevogel and Jaime Paglia originally served as showrunners during the first season before being replaced by Michael Gans and Richard Register in the second season, because of creative differences. The series is produced by Dimension Television and MTV Production Development, and was formerly filmed in Louisiana, in locations such as Baton Rouge and New Orleans as well as Chalmette High School.

Scream is an American anthology slasher television series developed by Jill Blotevogel, Dan Dworkin and Jay Beattie for MTV and is based on the slasher film series of the same name created by Kevin Williamson and Wes Craven.